By National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels
This ebook is the 6th quantity within the sequence Acute publicity guide degrees for Selected Airborne Chemicals, and contains AEGLs for chemical substances akin to ammonia, nickel carbonyl and phosphine, between others.
At the request of the dept of safety, the nationwide examine Council has reviewed the appropriate clinical literature compiled through a professional panel and demonstrated Acute publicity guide degrees (AEGLs) for 12 new chemical substances. AEGLs symbolize publicity degrees less than which antagonistic healthiness results are usually not more likely to take place and are precious in responding to emergencies resembling unintended or intentional chemical releases in the neighborhood, the office, transportation, the army, and for the remediation of infected sites.
Three AEGLs are licensed for every chemical, representing publicity degrees that lead to: 1) outstanding yet reversible ache; 2) long-lasting overall healthiness results; and three) life-threatening wellbeing and fitness impacts.
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Extra resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6
Species Variability Allylamine has been used experimentally to induce and study cardiovascular lesions in rats, dogs, calves, monkeys, and rabbits when administered intravenously, intradermally, orally, and/or by intraarterial injection (Boor et al. 1979; Boor and Hysmith 1987). The lesions were shown to be dependent on the metabolism of allylamine by SSAO, of which tissue levels were greatest in the aorta and coronary arteries (Lewinsohn et al. 1978; Conklin et al. 2001; Boor and Hysmith 1987; Lyles 1996).
1996 Benya and Harbison 1994 Budavari et al. 1996 HSDB 2003 Budavari et al. 1996 HSDB 2003 HSDB 2003 Benya and Harbison 1994 Verschueren 1996 HSDB 2003 Budavari et al. 5 ppm (Hine et al. 2). Additionally, if the methodology of van Doorn et al. , 14 ppm) found to be intolerable by humans (Hine et al. 1960). 7-ppm odor threshold was not reported, which may explain its discrepancy with the Hine et al. , a higher concentration may be needed for detection by sniffing for a few seconds than by inhalation for 5 min).
Genotoxicity Allylamine was not mutagenic in the Salmonella/microsome preincubation assay when tested at concentrations of 0, 1, 3, 10, 33, 100, 333, 1,000, or 3,333 µg/plate using strains TA98, TA100, TA1535, and TA1537. Testing was in the presence or absence of Aroclor-induced rat or hamster liver S9 (Zeiger et al. 1987). Negative results were also obtained by Lijinsky and Andrews (1980) with the Salmonella/microsome preincubation assay using strains TA98, TA100, TA1535, TA1537, and TA1538 (1-1,000 µg/plate) and by McMahon et al.
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6 by National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels