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Note, that given MRX-setup samples the relaxation curves starting from t1=400 μs so that typical magnetite MNP with d<20 nm do not contribute to the signal, significantly. MPS-measurements were performed on fluid suspensions of the MNPs at H=10 mT/μ0 and 25 kHz by means of a Magnetic Particle Spectrometer from Bruker BioSpin. In order to compare the data quantitatively, the iron concentration of the MNP suspensions were measured by Prussian Blue Staining after dissolution of MNP in hydrochloric acid.

1. FLUSPIO characateristics. a: Schematic diagram showing the mode of binding of FMN and GMP to the iron oxide cores in FLUSPIO. b-c: TEM images of USPIO (b) and FLUSPIO (c). Quantitative analysis of the images reveals that both types of nanoparticles have a core diameter of 5 ± 1 nm and a narrow size distribution. 005 µg) in comparison to Resovist in water. e: Fluorescence emission spectrum of FLUSPIO at different concentration in water. f: FLUSPIO uptake analyzed by means of fluorescence microscopy (FLUSPIO plus DAPI).

This may be attributed to the existence of a remanence magnetization of the ferromagnetic particles. Whereas by a decreasing magnetic field the Langevin function generates a decreasing magnetization, the ferromagnetic model includes a magnetization even if the magnetic field reaches zero. 20 S. M. Araújo-Moreira, and W. Zylka Due to the currently low saturation magnetization of the nanofluid ferromagnetic carbon the generation of a strong MPI signal will only be possible in the future when high concentrations will be obtainable.

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Airbus A320 SOP 08bNPA Approachmanaged

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