Get Biophysics of the Failing Heart: Physics and Biology of PDF

By R. John Solaro, Jil C. Tardiff

ISBN-10: 1461476771

ISBN-13: 9781461476771

ISBN-10: 146147678X

ISBN-13: 9781461476788

Subjects within the monograph “Biophysics of the Failing middle” contain cutting-edge chapters contemplating significant biophysical mechanisms for why hearts responding to obtained or inherited stressors input into maladaptive approaches finally resulting in an lack of ability of the center to reply successfully to hemodynamic so much specially in the course of workout. The chapters describe biophysical thoughts which have been utilized to figure out the triggers for the guts failure approach in addition to the mechanisms for maintaining the problems. those thoughts contain measurements of lively and passive mechanical houses and hemodynamics at degrees of association starting from molecules to hearts beating in situ. Biophysical techniques and methods also are utilized to choice of signaling and sign transduction, energetics, ionic currents, shipping procedures, electro-chemical and chemo-mechanical coupling. by means of its emphasis on biophysical facets of a usual scientific , the monograph is exclusive in its standpoint and concentration. The breadth of data within the chapters multi function position might be of price to clinicians and researchers in any respect degrees. glossy learn techniques and scientific knowing of middle failure calls for integration of a number of points of the issues. in general, combos of clinician scientists and researchers writer the chapters. a primary good thing about the e-book is couched in its didactic strategy including its emphasis on how biophysical recommendations and methods reduction in prognosis and improvement of latest therapies.

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Extra info for Biophysics of the Failing Heart: Physics and Biology of Heart Muscle

Sample text

Hobai, I. , & O’Rourke, B. (2001). Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure. Circulation, 103, 1577–1584. 77. , III, Weber, C. , Margulies, K. , Bers, D. , et al. (2003). Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circulation Research, 92, 651–658. 78. Marx, S. , et al. (2000). 6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts.

6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts. Cell, 101, 365–376. 79. , Curran, J. , Shannon, T. , Bers, D. , & Pogwizd, S. M. (2005). Ca2+/ calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circulation Research, 97, 1314–1322. 80. , et al. (2007). Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure.

This close association to the site of Ca entry allows it to be regulated by Ca at the level of single channel Ca entry. Ca-dependent activation of CaM leads to its interaction with an IQ motif in the C-terminus of the channel and the resulting structural changes lead to the inactivation of the channel [40]. Due to the dominant presence of the Na current in ventricular myocytes ICa,L despite its fast activation kinetic (~5 ms), does not contribute significantly to the upstroke of the cardiac AP.

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Biophysics of the Failing Heart: Physics and Biology of Heart Muscle by R. John Solaro, Jil C. Tardiff


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