New PDF release: Computer-aided drug design and delivery systems

By Ahindra Nag

ISBN-10: 0071701249

ISBN-13: 9780071701242

ISBN-10: 0071701257

ISBN-13: 9780071701259

ISBN-10: 0071764275

ISBN-13: 9780071764278

ISBN-10: 7100701244

ISBN-13: 9787100701242

"This state-of-the-art quantity reports the most recent breakthroughs in CADD (Computer-Aided Drug Design), drug supply structures, and allowing technologies"--Provided via publisher.

Show description

Read Online or Download Computer-aided drug design and delivery systems PDF

Similar biomedical engineering books

Download e-book for kindle: Multi-Modality Microscopy by Hanry Yu, Pao-Chun Lin, Fu-Jen Kao

This ebook covers very important facets of contemporary optical microscopy and photo recovery applied sciences. rather than natural optical therapy, the ebook is brought with the respect of the scientists who make the most of optical microscopy of their day-by-day learn. besides the fact that, adequate info are supplied in easy imaging ideas, optics and instrumentation in microscopy, round aberrations, deconvolution and photograph recovery.

Download e-book for iPad: Principles of Tissue Engineering by Robert Lanza

First released in 1997, ideas of Tissue Engineering is the generally well-known definitive source within the box. The 3rd variation presents a far wanted replace of the fast development that has been completed within the box, combining the must haves for a basic realizing of tissue progress and improvement, the instruments and theoretical details had to layout tissues and organs, in addition to a presentation through the world's specialists of what's at present recognized approximately each one particular organ approach.

Read e-book online 4th International Workshop on Wearable and Implantable Body PDF

This ebook includes papers from the foreign Workshop on Wearable and Implantable physique Sensor Networks, BSN 2007, held in March 2007 on the college health center Aachen, Germany. subject matters lined within the quantity contain new scientific measurements, clever bio-sensing textiles, low-power instant networking, approach integration, clinical sign processing, multi-sensor facts fusion, and on-going standardization actions.

Benjamin Loret, Jacques M. Huyghe's Chemo-Mechanical Couplings in Porous Media Geomechanics and PDF

The publication addresses basic matters confronted by means of experimentalists, modelers and engineers drawn to diverse actual, mechanical and delivery features of organic tissues and chemically energetic geological fabrics, more often than not clays and shales. the focal point is at the couplings among electro-chemical and mechanical features excited by swelling and chemical consolidation.

Extra resources for Computer-aided drug design and delivery systems

Example text

For drugs that obey a one-compartment model, the apparent volume of distribution is V = dose/Co where Co is the initial drug concentration. 3â•… Metabolism The metabolic conversion of a drug into another chemical form must be considered in the design of drug delivery systems. For this reason, it is necessary to keep information on the location, rate, and extent of metabolism and the rate constant for the process. The two important factors associated with the metabolism of the drug are first the ability of the drug to induce or inhibit enzyme synthesis that results in a fluctuating blood drug level with chronic dosing.

However, they suffer from all the shortcomings of the de novo design packages. The combinatorial nature of the algorithm leads to the generation of undesired chemical structures that may be unstable or synthetically unfeasible. 11â•… RACHEL Software Package RACHEL stands for real-time automated combinatorial heuristic enhancement of lead compounds and is a drug optimization package written by Chris M. W. Ho of Drug Design Methodologies, LLC. This program is designed to optimize weakly binding lead compounds in an automated combinatorial fashion.

Thus a means of rapidly crossreferencing chemical components on demand is available. RACHEL implements random sampling in the initial stages of lead compound optimization. RACHEL also incorporates a heuristic active-site mapping algorithm to determine the optimal chemical characteristics to complement a given region of the active site. In addition, RACHEL can determine the chemical characteristics to complement the receptor, can provide a list of candidate fragments and substitute them in a combinatorial fashion, and also can cross-reference other database components that exhibit similar characteristics.

Download PDF sample

Computer-aided drug design and delivery systems by Ahindra Nag


by Jeff
4.2

Rated 4.09 of 5 – based on 35 votes