Download PDF by Byron Jones, Michael G. Kenward: Design and Analysis of Cross-Over Trials, Third Edition

By Byron Jones, Michael G. Kenward

ISBN-10: 0412606402

ISBN-13: 9780412606403

ISBN-10: 1439861420

ISBN-13: 9781439861424

ISBN-10: 1439861439

ISBN-13: 9781439861431

The first version of Design and research of Cross-Over Trials speedy grew to become the traditional reference at the topic and has remained so for greater than 12 years. In that point, besides the fact that, using cross-over trials has grown quickly, rather within the pharmaceutical area, and researchers have made a couple of advances in either the idea and strategies acceptable to those trials.

Completely revised and up to date, the long-awaited moment variation of this vintage textual content keeps its predecessor's cautious stability of concept and perform whereas incorporating new methods, extra information units, and a broader scope. improvements within the moment version include:

  • A new bankruptcy on bioequivalence
  • Recently built tools for studying longitudinal non-stop and express data
  • Real-world examples utilizing the SAS system
  • A finished catalog of designs, datasets, and SAS courses on hand on a spouse website at

The authors' exposition supplies a transparent, unified account of the layout and research of cross-over trials from a statistical point of view besides their methodological underpinnings. With SAS courses and a radical therapy of layout matters, Design and research of Cross-Over Trials, moment variation sets a brand new ordinary for texts during this region and certainly can be of direct useful worth for years to come.

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Additional info for Design and Analysis of Cross-Over Trials, Third Edition

Sample text

3. 3: Group-by-period means for the mean PEFR data. Group 1 (AB) n1 = 27 2 (BA) n2 = 29 Mean Period 1 y¯11. 84 y¯21. 1. 38 Period 2 y¯12. 20 y¯22. 2. 52 Mean y¯1.. 52 y¯2.. 08 y¯... 2 Plotting the data As with the analysis of any set of data, it is always good practice to begin by drawing and inspecting graphs. A “feel” for the data can then be obtained and any outstanding features identified. We begin by plotting for each patient, within each group, the mean PEFR in Period 2 vs the mean PEFR in Period 1.

Testing π1 = π2 (assuming λ1 = λ2 ) In order to test the null hypothesis that π1 = π2 , we use the “cross-over” differences c1k = d1k = y11k − y12k for the kth subject in Group 1 and c2k = −d2k = y22k − y21k for the kth subject in Group 2. Note that because any carry-over effect that is common to both treatments is part of the period effect, we can set λ1 = −λ2 . Then, if λ1 = λ2 , both must be zero, E[c1k ] = π1 − π2 + τ1 − τ2 and E[c2k ] = π2 − π1 + τ1 − τ2 . If π1 = π2 , these expectations are equal and consequently to test the null hypothesis we apply the two-sample t-test to the cross-over differences.

The main aim of the cross-over trial is therefore to remove from the treatment (and period) comparisons any component that is related to the differences between the subjects. In clinical trials it is usually the case that the variability of measurements taken on different subjects is far greater than the variability of repeated measurements taken on the same subject. The cross-over trial aims to exploit this feature by making sure that, whenever possible, important comparisons of interest are estimated using differences obtained from the within-subject measurements.

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Design and Analysis of Cross-Over Trials, Third Edition by Byron Jones, Michael G. Kenward

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